Round-up: Edin Dzeko treble destroys Villarreal, Lyon thrash Alkmaar

The Bosnian's treble came after Emerson Palmieri opened the scoring in Spain, leaving Villarreal with a mountain to climb in the return leg.

Dzeko has now scored 28 competitive goals this season for Roma and is currently the top scorer in both Serie A and the Europa League.

Elsewhere, Lyon made light work of AZ Alkmaar in the Netherlands as they began the knockout phase with Alexandre Lacazette scoring twice in a 4-1 victory, while Fiorentina edged Borussia Moenchengladbach 1-0 in Germany.

Lyon will take a commanding lead into their second leg against AZ Alkmaar after teenager Lucas Tousart scored his first senior goal for the club and Jordan Ferri rounded off the scoring in stoppage time either side of Lacazette's double.

Alireza Jahanbakhsh had reduced the deficit for AZ with a 68th-minute penalty.

Gladbach came into their encounter with Fiorentina on a hot streak having won their last four games and they dominated possession and made several chances against the Italians.

The Serie A side were resilient at the back, however, and grabbed the only goal when Federico Bernardeschi fired home a fine free kick in the dying seconds of the first half.

Elsewhere, Shakhtar Donetsk won 1-0 at Celta Vigo with a 27th-minute goal from Gustavo Blanco Leschuk, while Sparta Prague were thrashed 4-0 at Rostov and FC Krasnodar beat visitors Fenerbahce 1-0.