The Norwegian's skiing speed saw him pull clear of his rivals to take victory and start his campaign in the best possible fashion.
After the win, he commented: "I do not think I have the margin on the tracks that I had last season. It has disappeared. It will be harder to get sprint wins this year.
"I did not think there was that big of a chance to win compared to last year, but I did and am proud of that."
Bø's older brother Tarjei also ended the competition with one shooting penalty, crossing the line as runner-up 19 seconds down, Russia's Matvey Eliseev shot clean for third and fourth went to Alexander Loginov, with one penalty, 27.1 seconds back.