The duo look strong in Altenberg, leading by 0.94 seconds after clocking times of 54.00s and 54.09s in the first two runs as Friedrich seeks his sixth world title and Margis his fifth.
Germany currently own the top four places in the standings as Nico Walther and Franke Eric are second, while Johannes Lochner and Christopher Weber lead Richard Oelsner and Malte Schwenzfeier by one hundredth of a second to sit third.
The final two runs are on Sunday afternoon, when Friedrich and Margis will be keen to turn their strong position into another world title.
Bobsleigh gold sweep for Germany in Innsbruck World Cup
Britain’s Hall shows the bobsleigh hype is real - but it’s been a journey
British quartet claim silver in Bobsleigh World Championships