Annemiek van Vleuten won the opening stage of Volta Valenciana despite a crash on the final descent.
The Movistar rider fell after powering clear on the final climb and opening up a lead of nearly four minutes.
The healthy advantage meant that she was able to get back on her bike and still secure the stage win by a comfortable margin.
Brave Brooks battles back from BMX horror crash to land brilliant Olympic bronze
A two-rider breakaway of Omer Shapira (Canyon-SRAM) and Heidi Franz (Rally Cycling) led the way earlier in the 125km stage from Barxeta to Gandía.
Shapira rode away from Franz around halfway through the stage and managed to stay clear for the penultimate climb up Alto Barxeta.
However, she was caught up the biggest climb of the day, the category 2 Alto Barx, by Van Vleuten and Ale BTC Ljubljana's Mavi Garcia.
Van Vleuten managed to get away from Garcia with 15km remaining and rode to victory despite falling.
The second stage covers 130km between Castellon and Vila-Real and features two main climbs. Defending champion Anna van der Breggen is not participating in the race this year.
You can watch the Giro d'Italia live and ad-free on the Eurosport app and Eurosport.co.uk. Download the Eurosport app for iOS and Android now. You can also watch the most comprehensive live & ad-free racing on GCN+. Go deeper and get interactive with live polls & quizzes, plus rider profiles, race updates, results & more – plus stream exclusive cycling documentaries. Watch it all with GCN+ on any device.
Clásica San Sebastián
Powless sprints to Clasica Cicliste San Sebastian victory
Charlotte Worthington's out of the kitchen and into the Olympic fire