The Ecuadorian rider suffers from a significant contusion in his right shoulder, as well as several bruises, after a crash sustained in the Profronde van Etten-Leur criterium in the Netherlands, last Sunday. In spite of treatment received all over the week and the lack of fractures, the injury's evolution has advised for further precautions to allow it healing completely, which rules out against his appearance in the race.
Carapaz will be replaced in the team by Jose Joaquin Rojas, who was the named reserve and already on-call in Alicante.
Movistar's eight-man team also includes general classification contenders Alejandro Valverde and Nairo Quintana, but the loss of climbing specialist Carapaz will be a blow to the team's ambitions.
Carapaz is strongly rumoured to be in his final weeks as a Movistar rider, with a move to Team Ineos expected for the 2020 season.
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"Carapaz was rightly considered one of the favourites to win La Vuelta and looked to be in the sort of form to make him Movistar's main man in the third Grand Tour of the summer.
"His performance at the Giro was impressively strong and his absence will be a loss for the race. Stand-out race favourite Primoz Roglic has just lost a major rival, while Movistar's hopes will now rest on the frustratingly inconsistent Nairo Quintana and 39-year-old Alejandro Valverde.
"The cynical will suggest that Carapaz's absence has more than a little to do with his impending move to Ineos, but starting a Grand Tour with such a level of pre-existing injury is a legitimate reason for his withdrawal from the start list."
-- Tom Bennett
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