Goalkeeper David De Gea left the field injured on the hour mark as Spain's Euro 2020 qualifier with Sweden ended 1-1.
A stoppage-time strike by substitute Rodrigo cancelled out Marcus Berg's opener for Sweden and gave Spain the draw they needed to qualify for Euro 2020 in a Group F game that finished 1-1 on Tuesday.
Spain dominated the opening 20 minutes and looked set to easily book their berth in next year's finals but Sweden goalkeeper Robin Olsen pulled off a string of superb saves as his side grew into the game.
Striker Berg put Sweden in front early in the second half after his initial header was saved, as was Emil Forsberg's shot, but Berg nodded home from close range at the second attempt to give his side the lead.
Spain goalkeeper David De Gea had been superb until he left the fray injured on the hour mark and, despite plenty of possession, the Spaniards had to wait until stoppage time before Rodrigo finally found a way past Olsen, firing home to send his group-leading side to the finals.
De Gea's Manchester United are set to meet leaders Liverpool in the Premier League on Sunday.
United released a statement on Tuesday evening which did confirm that it was a suspected muscle injury although it did not give any further information.
"Manchester United goalkeeper David De Gea was withdrawn with an apparent muscular injury during Spain’s 1-1 away draw with Sweden on Tuesday night.
"The Reds' no.1 appeared to pick up the problem when he took a goal-kick during the second half of his country’s Euro 2020 qualifier in Stockholm.
"After kicking the ball, De Gea immediately gestured to the Spain bench and was replaced by Chelsea stopper Kepa Arrizabalaga.
"Prior to the injury, David played superbly for Spain, making several impressive saves.
"De Gea's fitness will no doubt be a concern for Ole Gunnar Solskjaer ahead of this weekend’s huge Premier League clash with Liverpool at Old Trafford, and the boss could give an update on the Spaniard’s chances of playing during his pre-match press conference on Friday."