Aurier was a deadline day signing from PSG to replace Kyle Walker but he was left on the bench for the 3-0 win away at Everton.
He comes in tonight to replace Kieran Trippier at right-back with Mousa Dembele coming in for Moussa Sissoko in midfield.
Further forward Son Heung-min replaces Dele Alli, who is suspended following a red card in last year's Europa League.
Dortmund have a number of injuries with captain Marcel Schmelzer, Marc Bartra, Julian Weigl and Marco Reus amongst those injures.
However they still name a strong team with Shinji Kagawa, Christian Pulisic and summer signing Andriy Yarmolenko starting behind Pierre-Emerick Aubameyang.
TEAMS IN FULL
Tottenham Hotspur - Lloris (C), Aurier, Alderweireld, Sanchez, Vertonghen, Davies, Dier, Dembele, Eriksen, Son, Kane.
Borussia Dortmund - Bürki, Piszczek, Sokratis (C), Toprak, Toljan, Sahin, Dahoud, Kagawa, Aubameyang, Yarmolenko, Pulisic