Real Madrid's Sergio Ramos has tested positive for Covid-19, according to the club.
In a statement on their official website, Real posted: "Real Madrid C. F. informs that our player, Sergio Ramos, has tested positive in the last COVID-19 test that he has taken."
The club captain had already been sidelined with a muscle injury playing for Spain against Kosovo during the recent international break.
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Ramos, 35, had already been ruled out of both legs of the Champions League quarter-final tie with Liverpool as well as Real's table-topping win over Barcelona in La Liga.
He is expected to isolate for the next ten days, ruling him out of the upcoming Liga matches against Getafe and Cadiz respectively.
Zinedine Zidane's side have so far been able to cope in Ramos' absence, beating Liverpool in their quarter final first leg in Europe as well as the Clasico victory domestically.
Having seen his side take a 3-1 first leg lead over the Reds, Ramos will be hoping they can navigate the return match at Anfield.
Should the 13-time winners make it through, they will face the winner of the Porto v Chelsea tie, in which the Blues hold a 2-0 first leg lead.
Ramos will be expected to be out of isolation by then but it remains to be seen if he will have fully recovered from his injury.

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