Infantino, speaking at a news conference, said FIFA had made the decision at their council meeting on Friday.
His comments came after the European Club Association wrote a letter asking him not make a decision at this time and saying they would not take part in 2021 tournament.
Infantino said he believed a 48-team World Cup in 2022 in Qatar is "feasible", adding that FIFA would continue to study the options.
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"If it happens -- fantastic. If it doesn't happen -- fantastic also," he said.
No decision will be made on expanding that tournament, with possible additional host nations, until June, Infantino said.
The FIFA Council also decided to use VAR video review technology at June's Women's World Cup in France.
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