The clash signals a new era for Real Madrid as new boss Julen Lopetegui faces his first proper outing without the departed Cristiano Ronaldo, who left the Spanish capital for Juventus in July.
Keylor Navas gets the nod in goal, with recent recruit Thibaut Courtois ineligible to play against his former side due to paperwork issues. Luka Modric is on the bench.
Atletico manager Diego Simeone fields Antoine Griezmann and Diego Costa in attack, with summer signing Thomas Lemar expected to line up on the left flank.
[FOLLOW LIVE: REAL MADRID v ATLETICO MADRID]
Real Madrid: Navas, Carvajal, Varane, Ramos, Marcelo, Casemiro, Kroos, Isco, Bale, Asensio, Benzema.
Atletico Madrid: Oblak; Juanfran, Savic, Godin, Lucas Hernandez; Koke, Rodri, Saul, Lemar; Diego Costa, Griezmann.