The FA Cup represents Arsenal’s only real hope of securing silverware this season having been beaten 10-2 by Bayern Munich in the Champions League and Wenger has shown the Imps requisite respect by naming a strong side.
Apparent wantaway striker Alexis Sanchez starts in a front four that also includes Theo Walcott, Alex Oxlade-Chamberlain and Olivier Giroud.
Mesut Ozil is fit enough only for a spot on the bench.
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The National League leaders have captured the imagination with a run which started in the fourth-qualifying round against Guiseley.
The Imps upset Championship side Ipswich following a third-round replay and then Brighton ahead of beating Premier League Burnley 1-0 at Turf Moor but face a tough task at the Emirates.
Matt Rhead returns to the starting XI having been rested in midweek for the four-goal win at Braintree Town.
Arsenal team: Cech; Bellerin, Mustafi, Koscielny, Gibbs; Ramsey, Xhaka; Walcott, Oxlade-Chamberlain, Sanchez; Giroud. Subs: Martinez, Gabriel, Monreal, Coquelin, Iwobi, Ozil, Lucas.
Lincoln City: Farman, Wood, Habergham, Waterfall, Muldoon, Power, Rhead, Hawkridge, Raggett, Arnold, Woodyard... Subs: Etheridge, Marriott, Margetts, McMenemy, McCombe, Calder, Ward.
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