Maxwel Cornet and Moussa Dembele also scored to put third-placed Lyon on 69 points, four above fourth-placed St Etienne, who secured a Europa League berth with a 3-0 win over Nice.
Should Chelsea beat Arsenal in the Europa League final, Lyon will be spared the third qualifying round and go straight into the group stage of next season's Champions League.
Champions Paris St Germain thrashed lowly Dijon 4-0 at the Parc des Princes and Dijon will go into the relegation playoffs.
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A few hours after the OL women snatched a sixth Champions League title, the men secured their place in next season's competition.
Dutchman Depay put them ahead after being set up by Cornet, who doubled the tally with a curled shot before Dembele, who missed a first-half penalty, added a third and Depay volleyed home the fourth.
Lyon cannot finish second, however, as Lille, who crushed Angers 5-0, have 75 points.
Before being presented with the champions' trophy at the Parc des Princes, PSG thrashed Dijon with goals by Angel Di Maria and Edinson Cavani, and a Kylian Mbappe double.
Di Maria opened the scoring with a fine curling shot before setting up Cavani and Mbappe added a third from close range before halftime.
PSG were without Brazil forward Neymar, who was suspended for hitting a fan following their defeat in the French Cup final by Stade Rennais.
The 20-year-old Mbappe scored again in the second half, becoming the first French player to net 32 goals in Ligue 1 since Philippe Gondet's 36 for Nantes in the 1965-66 season.
Monaco were relieved after goals by Radamel Falcao and Alexandre Golovin earned them a 2-0 home win over Amiens to lift them up to 16th, three points above Caen who are in the relegation playoff spot.
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