Lille lost 3-2 to Brest in their first defeat of the season in Ligue 1.
Burak Yilmaz's double was not enough to make up for a three-goal deficit following headers by Ronael Pierre-Gabriel and Romain Perraud and an Irvin Cardona strike in the first half.
The result left second-placed Lille, who impressed in a 3-0 win at AC Milan in the Europa League on Thursday, on 19 points, five behind PSG who beat Stade Rennais 3-0 at home on Saturday.
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Brest moved up to 13th on 12 points.
Lyon moved up to fifth on 17 points with a 2-1 derby victory over St Etienne. Monaco are sixth, also on 17 points, after a 2-1 win at Nice.
St Etienne went ahead five minutes before the break when Lyon keeper Anthony Lopes deflected a Denis Bouanga cross into his own net before Tino Kadewere equalised in the 65th minute from Maxwel Cornet's cross.
Kadewere secured all three points for Lyon nine minutes later after slaloming through the visitors' defence, sending St Etienne, who missed a late penalty through Bouanga, down to 15th on 10 points.
In Brest, the home side opened the scoring in the 15th minute when Pierre-Gabriel headed home Perraud's cross.
Perraud made it 2-0 four minutes later with a fine half volley as Lille struggled to cope with the hosts' early pressure.
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Three minutes from the break, Brest added another as Cardona lobbed Mike Maignan with a header, only for Yilmaz to give Lille a lifeline on the stroke of halftime with a penalty after Paul Lasne fouled Jose Fonte.
Yilmaz further reduced the arrears 12 minutes into the second half with a deflected shot for his sixth Ligue 1 goal.
The Turkish striker had a golden opportunity to salvage a point for the visitors but his last-minute strike hit the crossbar.
Promoted RC Lens salvaged a 4-4 home draw against Stade de Reims in a dramatic encounter as Florian Sotoca scored in the 90th minute and one minute into added time before being denied a last-gasp penalty by the VAR.