The Belgium defender suffered a recurrence of the calf injury that kept him out for eight games after coming on as a substitute in Saturday's 4-1 win over Sunderland.
Striker Sergio Aguero, who is being eased back after heel trouble, could feature after being an unused substitute at the weekend. Defender Pablo Zabaleta and midfielder Fernando are back in training but not yet match-fit.
Casemiro tells Real he wants to join Man Utd, Ten Hag lines up Carrasco - Paper Round
Provisional squad: Hart, Caballero, Sagna, Mangala, Otamendi, Demichelis, Kolarov, Clichy, Maffeo, Toure, Fernandinho, Delph, De Bruyne, Sterling, Silva, Navas, Aguero, Bony, Iheanacho.
Conte ready to move on from Tuchel bust-up, VAR official Dean admits error for equaliser
UEFA Europa Conference League
Scamacca scores as West Ham hold two-goal advantage over Viborg
Share this article