Ndomble joined Spurs from Lyon for around £60 million in the summer transfer window. There is no place in the matchday squad for other new signings Giovani Lo Celso and Ryan Sessegnon.
Live coverage of Spurs v Aston Villa
Aston Villa are unrecognisable from the side that was promoted from The Championship, though Jack Greaish captains the side:
Lloris, Walker-Peters, Alderweireld, Sanchez, Rose, Winks, Sissoko, Ndombele, Lamela, Lucas, Kane. Subs: Gazzaniga, Aurier, Dier, Skipp, Wanyama, Eriksen, Nkoudou.
Aston Villa: Heaton, Elmohamady, Engels, Mings, Taylor, Hourihane, McGinn, Grealish, Trezeguet, El Ghazi, Wesley. Subs: Steer, Konsa, Targett, Luiz, Lansbury, Jota, Kodjia.