The Catalans are without captain Andres Iniesta for the encounter at the Santiago Bernabeu, where the Catalans look to overturn a 3-1 deficit.
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Javier Mascherano comes in and looks set to form a back three along with Gerard Pique and Samuel Umtiti, with Sergi Roberto and Jordi Alba patrolling the wide areas.
Andre Gomes plays in support of Lionel Messi and Luis Suarez.
For Real Madrid Gareth Bale and Isco are both on the bench as Lucas Vázquez and Marco Asensio make up the front three alongside Karim Benzema, with Cristiano Ronaldo serving the first of his five-match ban.
Keylor Navas, Carvajal, Sergio Ramos, Varane, Marcelo, Kovacic, Modric, Kroos, Lucas Vázquez, Asensio & Benzema. Subs: Casilla, Nacho, Bale, Casemiro, Theo, Isco, Ceballos.
Ter Stegen; Umtiti, Mascherano, Pique; Sergio Roberto, Busquets, Rakitic, Alba; André Gomes, Suarez, Messi. Subs: Cillessen, Semedo, Denis Suárez, Deulofeu, Alcácer, Digne, Aleix Vidal.
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