The on-loan central defender impressed manager Ronald Koeman after coming on against Manchester City at the weekend as a substitute for Fonte, who suffered a cut on his knee that required stitches.
Beyond Fonte and long-term absentees Jay Rodriguez, who will miss the coming seven to eight weeks following ankle surgery, Fraser Forster and Florin Gardos, Koeman has a fully-fit squad from which to choose.
'I'm fighting for my son' - Lukaku urges social media CEOs to meet players to stop online abuse
Team from: Soares, Bertrand, Caulker, Clasie, K Davis, S Davis, Gazzaniga, Isgrove, Juanmi, Long, Mane, Martina, Pelle, Ramirez, Stekelenburg, Tadic, Van Dijk, Romeu, Wanyama, Yoshida.
Analysis: Block midfield, attack wing-backs – How Guardiola can end Tuchel hoodoo
Jack Growlish! - Dribbling dog stops play in Bosnia