The Dutch have opted to use their Champions League stars, with Virgil van Dijk and Georginio Wijnaldum both starting in an XI that also features Ajax talents Mathias de Ligt and Frenkie de Jong.
"Much of the pre-game talk surrounded whether Harry Kane would start," said Eurosport's football expert Marcus Foley from the stadium in Guimaraes.
"He doesn’t, but actually Gareth Southgate’s decision to not select any of the players used in the Champions League Final has a bigger impact in midfield, where Fabien Delph starts alongside Ross Barkley and Declan Rice.
"There’s not a lot of experience in there and some of those players are a substantial downgrade on Jordan Henderson and Dele Alli. It’s also where Netherlands are probably strongest … they could really take control of the game in there."