"It's crazy. This schedule doesn't make sense," the Portuguese told reporters on Tuesday.
"In our case we are the team who has more competitions already and we are going to play with 45 hours between games, it's absurd. It's one of the issues every time we have a meeting with the FA, we try to make them understand what it means to the players. It's not human, the amount of games we have.
"If we increase that with international players it becomes really tough. If someone can come and say 'Look, this is the reason', I will try to understand. But at the moment it doesn't make sense."
Despite their workload Wolves are sixth in the Premier League after going unbeaten for nine games and have qualified for the last 32 of the Europa League with a game to spare.
"It says a lot about the players," he said. "We have a strong group of players who are committed to the idea." (Reporting by Martyn Herman; Editing by Hugh Lawson)