Defending champions Ciudad, the sole remaining Spanish team in the competition, were paired with HSV Hamburg in a repeat of last year's last four clash which the Liga ASOBAL club edged 60-59 on aggregate.
2007 winners Kiel will face fellow Bundesliga outfit Rhein-Neckar Loewen.
THW, who are unbeaten in 26 league games this season and who have lost just one of their 14 Champions League matches, will be heavy favourites against the Mannheim outfit who are making their debut in Europe's premier competition.
Loewen face uphill task against Kiel
EHF Champions League
HSV Hamburg v BM Ciudad Real
THW Kiel v Rhein-Neckar Löwen
RK Gorenje v TSV St. Otmar St. Gallen
VfL Gummersbach v CAI BM. Aragon
Cup Winners' Cup
Kadetten Handball v HSG Nordhorn
ZMC Amicitia Zürich v Pevafersa Valladolid
Men's Challenge Cup
Besiktas JK v UCM Sport Resita
CSU Suceava v BSV Bern Muri
Medvedi edge Lowen
Incredible handball goals at the Olympics