Crutchlow was forced out of the Australian Grand Prix when he suffered a major high-speed fall at Turn 1 during Friday afternoon's second practice session.
He had surgery on his right tibia the following morning having been airlifted to hospital in Melbourne.
After several days to allow the swelling to reduce, the Briton was operated on again on Thursday - this time on his ankle.
Australian Grand Prix
Crutchlow out of Australian GP with broken ankle
26/10/2018 AT 13:14
It is expected Crutchlow will be able to return to his home on the Isle of Man as early as Sunday to begin his recovery.
Honda test rider Stefan Bradl is taking his place on the LCR machine this weekend at Sepang.
It will be his fourth MotoGP outing of the season, after two wildcard runs with the factory Honda team and a stand-in appearance for Marc VDS when Franco Morbidelli was injured in Germany.
Although not yet confirmed, it appears unlikely Crutchlow will be fit in time for the season finale at Valencia in two weeks' time.
Bradl will stand in again if this is the case.
Australian Grand Prix
Iannone tops FP2, Crutchlow in heavy crash
26/10/2018 AT 06:58
Australian Grand Prix
Lorenzo to miss Australian GP as well
21/10/2018 AT 06:06