The Spaniard had looked set to complete a memorable American double in 2009 by winning at both Laguna Seca and Indianapolis before his incident early in the Indy race, having dominated practice and qualifying.
The Repsol Honda rider, who had been on pole by over half a second, rejoined in last and finished 10th in a race won by Jorge Lorenzo after title leader Valentino Rossi also crashed.
Pedrosa crashed out of the lead at Laguna Seca in this season's United States GP in July, but victory this weekend would be his third of the season. He has taken two wins a year since his 2006 MotoGP debut.
Grand Prix Valencia
'An inspiration for me' - Federer leads Rossi tributes after final race
14/11/2021 AT 17:23
“I’m going to Indianapolis in a very good mood and I’m feeling ready to finish the job we weren’t able to complete in the race there last time," said Pedrosa.
"I felt really comfortable riding in Indy last year. I was on top of the timesheets from the first practice, I took pole position and the only mistake I made was in the race.
"So I hope this time we can put together a strong weekend and take another good result."
Pedrosa arrives at round 11 second in the World Championship, but 77 points behind Lorenzo whom Pedrosa finished second to last time out at Brno.
"We were fast and consistent at the last race in Brno and we’ll be aiming to get straight back on that pace again this weekend," he said.
"It will be important, as always, to establish a good machine setting quickly on Friday, and I think we have a useful base from last year that will help us to find the right direction straight away.
"We were ready to win again in Brno and this will be our goal in Indianapolis too.
"Riding in America is different, the Indianapolis circuit is very impressive and I feel very good racing in the States because the support I get from the fans is always very positive. So I’m really looking forward to getting out there."
Pedrosa is close to agreeing a new contract with Repsol Honda for 2011, where he would join the already-signed Casey Stoner.
Rossi announces decision to retire at end of season
05/08/2021 AT 14:45
MotoGP star Jason Dupasquier dies after crash
30/05/2021 AT 11:01