The heavier light blues boat quickly pulled ahead at the start and they never wavered, turning the race into a procession as they crossed the line four lengths clear.
"Every other race I've done here, I've felt so nervous, but I felt really calm," Cambridge cox Hugo Ramambason said.
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"We wanted to get a good start, keep moving, and earn the right to win the race. Last year was real tough, but the attitude in the squad has been so good."
Cambridge also won the earlier women's race by an even larger margin while both Cambridge reserve crews won their races on a day of complete domination.
Oxford had won four of the previous five men's races.
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