Rugby Union-Vunipola brothers both injured in Saracens' win

The pair were injured at almost the same time in the first half with prop Mako immediately replaced after suffering a calf problem and Billy, who hurt his knee and later his arm, continuing until after the break when he too departed, the latest setback in 18 months marked by several injuries.

Both brothers, who have been named in England's training squad for the Autumn series, retreated to the bench, with Mako pictured with his leg in a protective brace and Billy with his arm packed in ice.

The injuries are piling up for England, with lock Joe Launchbury last week ruled out after knee surgery.

Bath full-back Anthony Watson and Exeter forward Sam Simmonds will also miss the games against South Africa, New Zealand, Japan and Australia.

England could ill afford to lose Mako Vunipola from the front row so soon after Joe Marler announced his international retirement.

England coach Eddie Jones names his squad for the November games on Thursday. (Reporting by Neil Robinson, editing by Pritha Sarkar)