But the world No 1 was in far more ruthless form this time around as he took to the table in York for the second time to face Mei, who had beaten veteran Ken Doherty in the first round.
Trump quickly opened up a 4-0 lead over the Chinese players with breaks of 68, 86 and then 105 but his opponent hit back in the fifth to avoid the whitewash, clearing the table with a visit of 127.
'Favourite's tag gives me edge even when I play badly' - Trump
And while it stopped Trump matching Ronnie O'Sullivan's 12 straight frames, he soon joined the defending champion in the third round with two more half-centuries of the highest quality to set up a clash with either Nigel Bond or Louis Heathcote.
The evening session saw the first major casualty as Mark Williams handed Michael White a 6-2 victory, the Welshman continuing his good record against his fellow countryman and the 2018 world champion.
Williams' potting ability deserted him in the opening mini-session as White took a 4-0 lead before withstanding a brief fightback to seal victory as the first winner of the evening session.
Graeme Dott was the first man of the day into the third round by that point after he racked up a whitewash over Yuan Sijun.
'Another brilliant pot' - Trump wows crowd with shot
Dott failed to make a single century in the match and did pass fifty, like Trump, on five separate occasions, closing out the victory with 99 in the final frame.
Ding Junhui made short work of Michael Georgiou to reach the third round, winning 6-2 with a break of exactly 100 to finish off the match.
And Ding was joined by fellow Chinese player Yan Bingtao, who hit back-to-back centuries to stamp his authority on the match before closing out a 6-2 victory over Stuart Carrington.
John Higgins was far from his fluent best but he secured a 6-1 victory in the evening, as did fellow Scot Stephen Maguire.