In the women's event Miho Takagi of Japan led after day one and she held on to top spot following the 1500m as she finished second, 0.32 seconds behind winner Wust.
But Takagi could only finish sixth in the 5000m and Wust was runner-up to Martina Sablikova to confirm her sixth World Allround crown and first since 2014.
Irene Schouten stars at ISU Speed Skating World Cup Finals
In the past two years Sablikova had held the title but she had to make do with silver this time around, while Takagi won bronze.
This was also 30-year-old Wust's 11th World Allround medal to equal German Claudia Pechstein's record, although fellow German Gunda Niemann-Stirnemann is still record champion with eight titles.
In the men's event Kramer held the lead after day one and he claimed a record-extending ninth World Allround title with ease as he finished second in the 1500m and first in the 10,000m.
And the Dutch celebrations continued as he was joined on the podium by compatriots Patrick Roest and Jan Blokhuijsen in second and third respectively.
Schouten stars at ISU Speed Skating World Cup Finals
Schouten and van der Poel claim World titles
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