Tsonga cruised to the 14th title of his career in 69 minutes as Pouille failed to put the 31-year-old any under real pressure.
Pouille was going for his second ATP World Tour crown after winning his maiden title at the Moselle Open in Metz last September.
But the 23-year-old struggled at times with his serve, landing about 60 per cent of his first-serve offerings.
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He was broken at the start of the match and again at 3-3 in the second set as Tsonga secured his second title of 2017.
Pouille also failed to dent Tsonga's serve, with the former Australian Open runner-up winning 87 per cent of his service points.
Tsonga never faced a break point as he added a third Marseille title to his collection after victories in 2009 and 2013.
It was Tsonga's second consecutive title as he won the ABN Amro World Tennis Tournament in Rotterdam last week by defeating then-world number 11 David Goffin.
Tsonga should now return to the top 10 at number seven when the new ATP rankings are revealed on Monday.