British number two Cameron Norrie is out of the Miami Open, but Australian Open runner-up Daniil Medvedev fought off leg cramps to reach the last-16.
Norrie was beaten by Taylor Fritz, who saw off the world number 56 with a 6-4, 3-6, 6-1 victory.
A set and 5-2 up, Medvedev looked to be in control of his match with Alexei Popyrin, before the Australian fought back to take the second set on a tie break to force a decider.
'I liked what Novak said' - Medvedev backs Djokovic over vaccine being 'personal'
But Russia’s world number two was beginning to feel the Florida heat, and required regular massages and electrolyte drinks to battle through cramp, before seeing out a 7-6, 6-7, 6-4 win - a result he is proud of given the circumstances.
Daniil Medvedev needed massages to fight off cramp during his Miami Open win
Image credit: Getty Images
“It’s probably one of the sweetest victories in my career, because I was cramping like hell in the third set,” Medvedev said in his on-court interview.
It’s one thing when you’re cramping when you’re [ahead], but I started cramping before. It was tough to think about the win in these conditions.
“At the same time, I should have won in two sets and we would not be talking about cramping. But anyway, we have the result on the board and I’m happy that I managed to go through all the difficulties of this definitely crazy match.”
John Isner booked his place in the last-16 with a 7-6, 7-6 win over Canadian Felix Auger-Aliassime, where he is joined by fellow American Frances Tiafoe, who came from a set down for the third match in a row to get past Serbian 16th seed Dusan Lajovic 1-6, 7-5, 6-3.
Finn Emil Ruusuvuori followed up his shock win over Alexander Zverev with another victory over Nordic rival Michael Ymer, while Roberto Bautista Agut, Jannik Sinner and Alexander Bublik also progressed.
How can Norrie qualify for ATP Finals? Who else is in contention?
Federer, Murray fall in major ranking shake-up; Norrie, Badosa into top 15