Before the game there were suggestions from Wawrinka's camp that the Swiss was struggling with flu-like symptoms, having been sick during his victory over Andreas Seppi.
However, he started well and took the opening set 6-4 without too much trouble.
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That was largely down to the fact that Isner himself was clearly struggling and he had to get the trainer on in the second set.

Wawrinka makes it through to last 16 after Isner retired injured

Eventually he had to retire at 4-1 down in the second which sent Wawrinka through.
The 2014 winner will meet Daniil Medvedev in the last-16 stage.
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