After receiving a bye into the second round, top seed Djokovic beat Shapovalov 6-3 6-3 to book a third-round meeting with John Isner, who overcame Lucas Pouille 7-5 6-3.
Dominic Thiem’s 7-6(3) 6-3 win over Pablo Carreno-Busta ensured there were only straight-set wins recorded on Wednesday.
Tennis
'It is time to kick out the Big Three' - Harris says next generation are here to stay
YESTERDAY AT 14:19
Earlier in the day, Alexander Zverev’s match with Jeremy Chardy was the tightest contest, with the German prevailing in both tie-breaks – including a marathon breaker in the first set – to win 7-6(13) 7-6(3).
Stefanos Tsitsipas also needed two tie-breaks to overcome Felix Auger-Aliassime 7-6(3) 7-6(3).
Seventh seed Karen Khachanov beat Taylor Fritz 6-2 6-4 to set up a meeting with Andy Murray’s conqueror Fabio Fognini.
Matteo Berrettini, Roberto Bautista Agut, Andrey Rublev and David Goffin also advanced to the third round.
US Open
'It's not acceptable' - Djokovic gets 'unfair treatment' compared to Federer and Nadal, says Becker
YESTERDAY AT 13:31
Laver Cup
Discovery Sports secures decade-long deal to show Laver Cup exclusively across Europe
YESTERDAY AT 09:36