Novak Djokovic of Serbia and Naomi Osaka of Japan hold their winners trophies at NBC's TODAY Show on September 10, 2018 in New York City
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Three-time US Open champion Djokovic, who comes into the tournament having won his fifth Wimbledon title, is followed in the seedings by 2017 winner Rafael Nadal.
Novak Djokovic: I have a few more years in my legs
Roger Federer will begin his quest for a 21st Grand Slam crown as the third seed. He is followed by Austrian Dominic Thiem, Russia's Daniil Medvedev and Germany's Alexander Zverev.
Former champions in the list of 32 men's seeds also include Marin Cilic (2014) of Croatia who is 22nd and Stan Wawrinka (2016) of Switzerland who is 23rd.
French Open winner Ash Barty is seeded second behind Japan's Osaka, followed by Czech Karolina Pliskova and Wimbledon champion Simona Halep.
Djokovic takes his hat off to Medvedev
American Serena Williams, last year's finalist who is seeking a record-equalling 24th Grand Slam title, is seeded eighth while another former winner, Sloane Stephens, is 11th.
Angelique Kerber, the 2016 champion, is seeded 14th.