Several players have voiced their fears that tennis may not return in 2020 at all but Mouratoglou says that Williams returned to the game after giving birth to her daughter to win Grand Slams and would jump at the opportunity to claim a record-equalling 24th major.
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"She's definitely come back to tennis to win Grand Slams, that's her goal," Mouratoglou told BBC Radio 4.
"For a player to be out of competition is extremely difficult. So the US Open will be a first opportunity to win one. There'll be a lot of restrictions and I have to speak with her to see if she will be able to accept and manage those expectations."
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Several of the sport's leading names, including Rafael Nadal and Novak Djokovic, believe the mooted social distancing protocols are too draconian, with only one person believed to be allowed in each player's entourage.
Mouratoglou believes that Williams would have a tough time being separated from her two-year-old daughter Alexis and joked that the child may need to coach her mother.
"I don't imagine her being three weeks without her daughter," he said.
"So she might have a new coach for the US Open, a bit younger. Considering our record in the last seven finals, her daughter might be more successful than me."