Norwegian Andreas Mikkelsen finished second, 48.4 seconds behind, with reigning champion Sebastien Ogier third for Citroen after overhauling Toyota's Kris Meeke who had a puncture in the final stage.
Northern Irishman Meeke was fourth, just 1.4 seconds off the podium.
Six-times world champion Ogier also took five bonus points from the final Power Stage, with Neuville taking three. The Belgian now has 110 points to his French rival's 100.
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Hyundai lead the manufacturers' championship with 157 points, 37 clear of closest challengers Toyota.
"The car has been absolutely perfect all weekend and I have felt comfortable, quick and in control throughout the event," said Neuville after his second win in a row following victory in Corsica last month.
The sixth round of the championship is in Chile on May 10-12. (Reporting by Alan Baldwin in London, editing by Pritha Sarkar)
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